The accident occurred about 8.45am this morning. A male passenger was also injured in the accident.

Emergency services, including Police, NSW Ambulance, NSW Fire & Rescue and Snowy Hydro Southcare attended the accident.

It took about 1.5 hours to free the driver, who was then transported by the Southcare helicopter to Canberra. The male passenger was taken by road ambulance to Yass Hospital.

It's understood the B-double had left from Adelaide and was carrying refrigeration equipment. The load spilled onto the road and a section of guard rail was taken out.

The woman suffered internal and facial injuries.

Captain Paul Hewett of NSW Fire & Rescue, Yass, said it was a "complicated entrapment".

"Every bit of gear we had was used [to free her]."

Upon arrival of the Snowy Hydro Southcare helicopter, the northbound lanes of the Hume Highway were closed.

One northbound lane remains closed, with traffic getting through at a reduced pace. The damaged truck was still onsite at 12pm and will have to be towed from the scene.

Southbound motorists on the Hume are unaffected.

The accident was the second truck accident on the Hume Highway near Yass in as many days with the Snowy Hydro helicopter called to both.

Diesel spill

In a second incident on the Hume Highway near Yass at 8am this morning, a truck punctured its diesel tank, spilling around 240 litres of fuel onto the highway.

The incident happened just south of Yass, near Burley Griffin Way, despite initial reports saying it was north of Yass.

Two Fire & Rescue NSW trucks attended the scene and cleaned up the spill, which took about 1.5 hours to mop up.

The area is now clear.