The valiant five firefighters up for the challenge are Nick Whiting, Ben Bowman, Mathew Carroll, Chris Inglis and Cameron Madden.

They will also be carrying 20 kilograms of gear as they race to the top of Sydney Tower Eye on 'C Day' as the crew is calling it (climb day) on Saturday, November 9.

Mr Whiting and Mr Bowman took part in the annual Firies Climb for MND last year and raised more than $3000. They're hoping to raise that target to more $5000 this year, having roped in a few of the other crew members.

"It will be nice to have a team involved this year," Mr Whiting said.

This will be Mr Whiting's fourth year taking part in the climb. He said he will be training more this year to beat his previous time up all 98 floors.

"My time was around 18 minutes last year and I'll be trying to beat that again. I had beat my time the year before that by two minutes," Mr Whiting said.

However, the challenge has a deeper meaning for the 600 firefighters who get involved.

Mr Whiting said his understanding of how MND affects people has grown in the four years he's taken part in the climb.

"I realised through fundraising that so many people in the Yass Valley have it or know someone who does. It was surprising," he said.

Each day, more than two people are diagnosed with MND in Australia, according to MND Australia.

MND sadly causes neurones that control muscles for movement, speech, breathing and swallowing to stop working properly. It can happen to anyone at any time.

The Firies Climb for MND has raised more than $2,000,000 since 2015 and $61,286 this year, so far.

The money goes to Macquarie University, Australia's largest MND research facility with 70 researchers and 12 clinicians who are working towards ending the disease.

As of Monday, the local firefighters had raised $515.

To give them a helping hand, visit fundraise.firiesclimbformnd.org.au/page/Yass511.