Anyone attending Saturday's rally has been asked to wear a face mask and has been told that social distancing will be enforced.

Recent changes to COVID-19 density rules in SA, which now allow one person to every two square metres at large gatherings, should make it easier for protesters to abide by virus restrictions.

Organisers said the rally came at a historic moment in the fight against systemic racism.

"In Australia, we see mining corporations destroying historic sites while Aboriginal communities are forced through the humiliation of cashless welfare," they said on Facebook.

"Other black and migrant communities also face over-policing, job discrimination and social inequality."

Police Commissioner Grant Stevens said a COVID-19 management plan had been submitted to SA Health for the event but he was unaware if it had yet been approved.

Mr Stevens said police would deploy the level of resources deemed necessary.

"We will have that level of response that is sufficient to address any concerns we have in relation to ensuring the safety of the people," he said.

Last month, more than 5000 people attended the first Black Lives Matter rally in Adelaide with police declaring they were happy with the event despite limited efforts at social distancing.

Plans for a second event the following week were scrapped after police said it would not get approval under the coronavirus restrictions in place at the time.

Australian Associated Press